Bax and Bak are members of the Bcl‐2 family and core regulators of the intrinsic pathway of
apoptosis. Upon apoptotic stimuli, they are activated and oligomerize at the mitochondrial …

Membranes of mammalian subcellular organelles contain defined amounts of specific
phospholipids that are required for normal functioning of proteins in the membrane. Despite …

Ectopic lipids play a key role in numerous pathologies, including heart disease, stroke, and
diabetes. Of all the lipids studied, perhaps the most well understood is cholesterol, a widely …

In recent decades, many sphingolipid enzymes, sphingolipid‐metabolism regulators and
sphingolipid transfer proteins have been isolated and characterized. This review will provide …

Besides their conventional role as energy suppliers for the cell, mitochondria in vertebrates
are active regulators of apoptosis. They release apoptotic factors from the intermembrane …

Ceramides are key intermediates in sphingolipid biosynthesis and potent signaling
molecules. However, excess ceramide is toxic, causing growth arrest and apoptosis. In this …

The sphingolipid family of lipids modulate several cellular processes, including proliferation,
cell cycle regulation, inflammatory signaling pathways, and cell death. Several members of …

Highlights•Drp1-SUMOylation stabilizes the ER/mitochondrial interface required for
apoptosis.•This ER/mitochondrial platform facilitates calcium and lipid fluxes during cell …

Ceramide and sphingomyelin (SM) are major components of the double membrane-bound
sphingolipids. Ceramide is an essential bioactive lipid involved in numerous cell processes …

The outer mitochondrial membrane is a busy place. One essential activity for cellular
survival is the regulation of membrane integrity by the BCL‐2 family of proteins. Another …