Optimal thyroid hormone replacement

J Jonklaas - Endocrine reviews, 2022 - academic.oup.com
Hypothyroidism is a common endocrinopathy, and levothyroxine is frequently prescribed.
Despite the basic tenets of initiating and adjusting levothyroxine being agreed on, there are …

Individualized therapy for hypothyroidism: is T4 enough for everyone?

MD Ettleson, AC Bianco - The Journal of Clinical Endocrinology …, 2020 - academic.oup.com
Context It is well recognized that some hypothyroid patients on levothyroxine (LT4) remain
symptomatic, but why patients are susceptible to this condition, why symptoms persist, and …

Levothyroxine dose adjustment to optimise therapy throughout a patient's lifetime

LH Duntas, J Jonklaas - Advances in therapy, 2019 - Springer
Levothyroxine is the standard therapy for patients with hypothyroidism, a condition that
affects up to 5% of people worldwide. While levothyroxine therapy has substantially …

To treat or not to treat subclinical hypothyroidism, what is the evidence?

J Calissendorff, H Falhammar - Medicina, 2020 - mdpi.com
Objective: levothyroxine prescriptions have increased remarkably during the last decade,
and it is most likely to be prescribed in subclinical hypothyroidism. The aim of this review …

[HTML][HTML] Thyroid function across the lifespan: do age-related changes matter?

JP Walsh - Endocrinology and Metabolism, 2022 - synapse.koreamed.org
Circulating concentrations of thyrotropin (TSH) and thyroxine (T4) are tightly regulated. Each
individual has setpoints for TSH and free T4 which are genetically determined, and subject …

Clinical outcomes after discontinuation of thyroid hormone replacement: a systematic review and meta-analysis

N Burgos, FJK Toloza, NM Singh Ospina, JP Brito… - Thyroid, 2021 - liebertpub.com
Background: Levothyroxine (LT4) is one of the most commonly prescribed medications.
Although considered a life-long replacement therapy, LT4 therapy can be discontinued for …

Off-label use and misuse of testosterone, growth hormone, thyroid hormone, and adrenal supplements: risks and costs of a growing problem

MS Irwig, M Fleseriu, J Jonklaas, NA Tritos, KCJ Yuen… - Endocrine Practice, 2020 - Elsevier
Over the past few decades, there has been an unprecedented rise in off-label use and
misuse of testosterone, growth hormone, thyroid hormone, and adrenal supplements …

Use of thyroid hormones in hypothyroid and euthyroid patients: a 2020 THESIS questionnaire survey of members of the Hellenic Endocrine Society.

SA Paschou, M Alevizaki, R Attanasio, L Hegedüs… - Hormones, 2022 - Springer
Purpose To investigate current practices of specialists in the use of thyroid hormone
preparations in Greece as part of an ongoing international survey, namely THESIS …

Prevalence and factors associated with chronic use of levothyroxine: a cohort study

C Janett-Pellegri, L Wildisen, M Feller, C Del Giovane… - Plos one, 2021 - journals.plos.org
Importance Levothyroxine prescriptions are rising worldwide. However, there are few data
on factors associated with chronic use. Objective To assess the prevalence of chronic …

The Relationship between Gastrointestinal Health, Micronutrient Concentrations, and Autoimmunity: A Focus on the Thyroid

M Ruscio, G Guard, G Piedrahita, CR D'Adamo - Nutrients, 2022 - mdpi.com
Currently, there is a lack of understanding of why many patients with thyroid dysfunction
remain symptomatic despite being biochemically euthyroid. Gastrointestinal (GI) health is …