The most common inflammatory disease of the airways is asthma among children affecting
around 235 million people worldwide. 5-Lipoxygenase (5-LOX) is a crucial enzyme which …

The products of 5-lipoxygenase are synthesized and released in the airway when an
asthmatic reaction occurs. 5-lipoxygenase via arachidonic acid metabolism produces …

Nitro fatty acids (NFAs) are endogenously generated lipid mediators deriving from reactions
of unsaturated electrophilic fatty acids with reactive nitrogen species. Furthermore …

Chronic obstructive pulmonary disease (COPD) is a progressive lung disease that is
commonly considered to be a potent driver of non-small cell lung cancer (NSCLC) …

Lipoxygenases (LOXs) are enzymes which found in organisms that catalyze the
peroxidation of polyunsaturated fatty acids (Arachidonic acid, Linoleic acid). The key role of …

Arachidonic acid (AA) is metabolized to diverse bioactive lipid mediators. Whereas the 5-
lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) …

Natural products comprise a rich reservoir for innovative drug leads and are a constant
source of bioactive compounds. To find pharmacological targets for new or already known …

ABSTRACT Introduction: Leukotrienes (LTs) are lipid mediators produced from arachidonic
acid with a broad variety of bioactivities in allergy and inflammation. The biosynthesis of LTs …

Tripterygium wilfordii glycosides (TWG) is a traditional Chinese medicine with effectiveness
against rheumatoid arthritis (RA), supported by numerous clinical trials. Lipid mediators (LM) …

The present study aimed to experimentally identify the essential oil of Algerian Cyperus
rotundus L. and to model the interaction of some known anti-inflammatory molecules with …