In recent years, considerable progress has been made in understanding the mechanisms
involved in platelet activation during hemostasis and thrombosis. Parallel-plate flow …

The mainstay of treatment for thrombosis, the formation of occlusive platelet aggregates that
often lead to heart attack and stroke, is antiplatelet therapy. Antiplatelet therapy dosing and …

Up to 1% of the population have mild bleeding disorders, but these remain poorly
characterized, particularly with regard to the roles of platelets. We have compared the …

Background Microfluidic devices recreate the hemodynamic conditions of thrombosis.
Methods Whole blood inhibited with PPACK was treated ex vivo with inhibitors and perfused …

Summary Background Aspirin and P2Y 12 antagonists are antiplatelet compounds that are
used clinically in patients with thrombosis. However, some patients are 'resistant'to …

Introduction To ease administration of medicines to people with dysphagia we developed
and patented a gel formulation within which whole tablets could be inserted. The aim was to …

Platelet adhesion and aggregation are key functions leading to thrombus formation. The
effect of aspirin, clopidogrel, and ticagrelor on platelet aggregation has been well …

Platelet function testing is essential for the diagnosis of patients with bleeding disorders.
Specifically, there is a need for a whole blood assay that is capable of analysing platelet …

目的研制一种合适的体外模型, 用以观察病理血管条件(包括狭窄, 血流紊乱, 静脉瓣膜受损等)
下血小板在血管壁的黏附功能. 方法本研究设计了一种改良的平板流动小室装置, 以不同剪切力 …

As the pathogenesis of arterial thrombosis often includes platelet adhesion and aggregation,
antiplatelet agents are commonly used to prevent thromboembolic events. Here, a new …