Oxidative stress and inflammation interact in the development of diabetic atherosclerosis.
Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species …

Patients with type 2 diabetes mellitus (T2DM) are at high risk for macrovascular
complications, which represent the major cause of mortality. Despite effective treatment of …

Lipotoxicity, originally used to describe the destructive effects of excess fat accumulation on
glucose metabolism, causes functional impairments in several metabolic pathways, both in …

Insulin resistance is a hallmark of type 2 diabetes mellitus and is associated with a metabolic
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …

Type 2 diabetes mellitus (T2DM) is characterized by multiple pathophysiologic
abnormalities. With time, multiple glucose-lowering medications are commonly required to …

Individuals with impaired glucose tolerance (IGT) and/or impaired fasting glucose (IFG) are
at high risk, not only to develop diabetes mellitus, but also to experience an adverse …

The important Third Edition of this successful book conveys a modern and integrated picture
of metabolism and metabolic regulation. Explaining difficult concepts with unequalled clarity …

Obesity has reached pandemic proportions and is associated with serious cardiometabolic
sequealae including insulin resistance, diabetes, dyslipidemia, hypertension, and …

In recent years, we've developed a much better grasp of the biological and other factors
associated with the development of obesity. Reflecting our evolving understanding of …

The pathological condition of insulin resistance prevents the neuroprotective effects of
insulin. Numerous studies have demonstrated that insulin resistance, as an independent risk …