Loss of E-cadherin is causal to pathologic changes in chronic lung disease
Epithelial cells line the lung mucosal surface and are the first line of defense against toxic
exposures to environmental insults, and their integrity is critical to lung health. An early …
exposures to environmental insults, and their integrity is critical to lung health. An early …
Effect of sub-chronic exposure to cigarette smoke, electronic cigarette and waterpipe on human lung epithelial barrier function
Background Taking into consideration a recent surge of a lung injury condition associated
with electronic cigarette use, we devised an in vitro model of sub-chronic exposure of human …
with electronic cigarette use, we devised an in vitro model of sub-chronic exposure of human …
Strong correlation between air-liquid interface cultures and in vivo transcriptomics of nasal brush biopsy
Air-liquid interface (ALI) cultures are ex vivo models that are used extensively to study the
epithelium of patients with chronic respiratory diseases. However, the in vitro conditions …
epithelium of patients with chronic respiratory diseases. However, the in vitro conditions …
Phenotypic epithelial changes in laryngotracheal stenosis
Objective Characterize and quantify epithelium in multiple etiologies of laryngotracheal
stenosis (LTS) to better understand its role in pathogenesis. Study Design Controlled in vitro …
stenosis (LTS) to better understand its role in pathogenesis. Study Design Controlled in vitro …
HDAC6 inhibitor ACY-1083 shows lung epithelial protective features in COPD
J Horndahl, R Svärd, P Berntsson, C Wingren, J Li… - PloS one, 2022 - journals.plos.org
Airway epithelial damage is a common feature in respiratory diseases such as COPD and
has been suggested to drive inflammation and progression of disease. These features …
has been suggested to drive inflammation and progression of disease. These features …