Epidemiology, pathophysiology, diagnosis, and management of cerebral toxoplasmosis

HM Elsheikha, CM Marra, XQ Zhu - Clinical microbiology reviews, 2020 - Am Soc Microbiol
Toxoplasma gondii is known to infect a considerable number of mammalian and avian
species and a substantial proportion of the world's human population. The parasite has an …

Toxoplasma gondii infection and its implications within the central nervous system

SK Matta, N Rinkenberger, IR Dunay… - Nature Reviews …, 2021 - nature.com
Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic
infections in humans. Although it normally only results in mild illness in healthy individuals …

[HTML][HTML] Control of human toxoplasmosis

NC Smith, C Goulart, JA Hayward, A Kupz… - International journal for …, 2021 - Elsevier
Toxoplasmosis is caused by Toxoplasma gondii, an apicomplexan parasite that is able to
infect any nucleated cell in any warm-blooded animal. Toxoplasma gondii infects around 2 …

In vitro production of cat-restricted Toxoplasma pre-sexual stages

AV Antunes, M Shahinas, C Swale, DC Farhat… - Nature, 2024 - nature.com
Sexual reproduction of Toxoplasma gondii, confined to the felid gut, remains largely
uncharted owing to ethical concerns regarding the use of cats as model organisms …

A unique Toxoplasma gondii haplotype accompanied the global expansion of cats

L Galal, F Ariey, MA Gouilh, ML Dardé… - Nature …, 2022 - nature.com
Toxoplasma gondii is a cyst-forming apicomplexan parasite of virtually all warm-blooded
species, with all true cats (Felidae) as definitive hosts. It is the etiologic agent of …

The pathogenicity and virulence of Toxoplasma gondii

SG Sanchez, S Besteiro - Virulence, 2021 - Taylor & Francis
Toxoplasma gondii is a parasitic protist infecting a wide group of warm-blooded animals,
ranging from birds to humans. While this infection is usually asymptomatic in healthy …

The transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony

JL Wang, TT Li, NZ Zhang, M Wang, LX Sun… - Nature …, 2024 - nature.com
Sexual development in Toxoplasma gondii is a multistep process that culminates in the
production of oocysts, constituting approximately 50% of human infections. However, the …

Dissecting histone deacetylase 3 in multiple disease conditions: selective inhibition as a promising therapeutic strategy

N Adhikari, T Jha, B Ghosh - Journal of Medicinal Chemistry, 2021 - ACS Publications
The acetylation of histone and non-histone proteins has been implicated in several disease
states. Modulation of such epigenetic modifications has therefore made histone …

DNA sequence and chromatin differentiate sequence-specific transcription factor binding in the human malaria parasite Plasmodium falciparum

VA Bonnell, Y Zhang, AS Brown, J Horton… - Nucleic Acids …, 2024 - academic.oup.com
Abstract Development of the malaria parasite, Plasmodium falciparum, is regulated by a
limited number of sequence-specific transcription factors (TFs). However, the mechanisms …

A positive feedback loop controls Toxoplasma chronic differentiation

MH Licon, CJ Giuliano, AW Chan, S Chakladar… - Nature …, 2023 - nature.com
Successful infection strategies must balance pathogen amplification and persistence. In the
obligate intracellular parasite Toxoplasma gondii this is accomplished through differentiation …