The different cell types of an organism share the same DNA, but during cell differentiation
their genomes undergo diverse structural and organizational changes that affect gene …

RUNX proteins belong to a family of metazoan transcription factors that serve as master
regulators of development. They are frequently deregulated in human cancers, indicating a …

A strong connection exists between the cell cycle and mechanisms required for executing
cell fate decisions in a wide-range of developmental contexts. Terminal differentiation is …

Epigenetics refers to mitotically and/or meiotically heritable variations in gene expression
that are not caused by changes in DNA sequence. Epigenetic mechanisms regulate all …

On entry into mitosis, many transcription factors dissociate from chromatin, resulting in global
transcriptional shutdown. During mitosis, some genes are marked to ensure the inheritance …

Tissue-specific transcription patterns are preserved throughout cell divisions to maintain
lineage fidelity. We investigated whether transcription factor GATA1 plays a role in …

The Runt‐related transcription factors (RUNX) belong to an ancient family of metazoan
genes involved in developmental processes. Through multiple protein‐interacting partners …

Despite successful therapeutic strategies in the prevention and treatment of arteriosclerosis,
the cardiovascular complications remain a major clinical and societal issue worldwide …

The highly reproducible inheritance of chromosomes during mitosis in mammalian cells
involves nuclear envelope breakdown, increased chromatin compaction, loss of long-range …

Mitosis is accompanied by dramatic changes in chromatin organization and nuclear
architecture. Transcription halts globally and most sequence-specific transcription factors …