In the last 5 years, most of the molecules that control mitochondrial Ca2+ homeostasis have
been finally identified. Mitochondrial Ca2+ uptake is mediated by the Mitochondrial Calcium …

Myoglobin is a cytoplasmic hemoprotein, expressed solely in cardiac myocytes and
oxidative skeletal muscle fibers, that reversibly binds O2 by its heme residue, a porphyrin …

The heart and those striated muscles that contract for long periods, having available almost
limitless oxygen, operate in sustained steady states of low sarcoplasmic oxygen pressure …

The diagnostic yield of exome and genome sequencing remains low (8–70%), due to
incomplete knowledge on the genes that cause disease. To improve this, we use RNA-seq …

Insulin and contraction are potent stimulators of GLUT4 translocation and increase skeletal
muscle glucose uptake. We recently identified the Rab GTPase-activating protein (GAP) …

We and others have suggested that bone marrow-derived progenitor cells may contribute to
the pathogenesis of vascular diseases. On the other hand, it was reported that bone marrow …

Mutations in the gene encoding the inner nuclear membrane proteins lamins A and C
produce cardiac and skeletal muscle dysfunction referred to as Emery Dreifuss muscular …

Myoglobin is a well-characterized, cytoplasmic hemoprotein that is expressed primarily in
cardiomyocytes and oxidative skeletal muscle fibers. However, recent studies also suggest …

Vascular endothelial growth factor (VEGF) is required for vasculogenesis and angiogenesis
during embryonic and early postnatal life. However the organ‐specific functional role of …

Although the primary function of myoglobin (Mb) has been considered to be cellular O2
storage and supply, recent studies have shown that Mb in addition can act as NO oxidase …