Natural products have had an immense influence on science and have directly led to the
introduction of many drugs. Organic chemistry, and its unique ability to tailor natural products …

Covering: 2000 up to 2020 This review presents select recent advances in the medicinal
chemistry of complex natural products that are prepared by total synthesis. The underlying …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Bryostatin 1 is a marine natural product that is a very promising lead compound because of
the potent biological activity it displays against a variety of human disease states. We …

Total Synthesis of Bryostatin 7 via C–C Bond-Forming Hydrogenation | Journal of the American
Chemical Society ACS ACS Publications C&EN CAS Find my institution Log In Journal of the …

Total Synthesis of Bryostatin 9 | Journal of the American Chemical Society ACS ACS
Publications C&EN CAS Find my institution Log In Journal of the American Chemical …

Modern methods for the identification of therapeutic leads include chemical or virtual
screening of compound libraries. Nature's library represents a vast and diverse source of …

Protein kinases are validated drug targets for a number of therapeutic areas, as kinase
deregulation is known to play an essential role in many disease states. Many investigated …

Bryostatin is in clinical trials for Alzheimer's disease, cancer, and HIV/AIDS eradication. It
binds to protein kinase C competitively with diacylglycerol, the endogenous protein kinase C …

Bryostatins are complex macrolactones isolated from marine organisms Bryozoan Bugula
neritina. They are potent modulators of protein kinase C isozymes (PKCα: ki= 1.3-188 nM) …