Early childhood general anaesthesia exposure and neurocognitive development
L Sun - British journal of anaesthesia, 2010 - academic.oup.com
A great deal of concern has recently arisen regarding the safety of anaesthesia in infants
and children. There is mounting and convincing preclinical evidence in rodents and non …
and children. There is mounting and convincing preclinical evidence in rodents and non …
Impact of anaesthetics and surgery on neurodevelopment: an update
RD Sanders, J Hassell, AJ Davidson… - British journal of …, 2013 - academic.oup.com
Accumulating preclinical and clinical evidence suggests the possibility of neurotoxicity from
neonatal exposure to general anaesthetics. Here, we review the weight of the evidence from …
neonatal exposure to general anaesthetics. Here, we review the weight of the evidence from …
Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised …
Background Preclinical data suggest that general anaesthetics affect brain development.
There is mixed evidence from cohort studies that young children exposed to anaesthesia …
There is mixed evidence from cohort studies that young children exposed to anaesthesia …
[HTML][HTML] Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of …
Background Neonates and infants requiring anaesthesia are at risk of physiological
instability and complications, but triggers for peri-anaesthetic interventions and associations …
instability and complications, but triggers for peri-anaesthetic interventions and associations …
Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain
Background Brief isoflurane anesthesia induces neuroapoptosis in the developing rodent
brain, but susceptibility of non-human primates to the apoptogenic action of isoflurane has …
brain, but susceptibility of non-human primates to the apoptogenic action of isoflurane has …
Ketamine-induced neuroapoptosis in the fetal and neonatal rhesus macaque brain
Background Exposure of rhesus macaque fetuses for 24 h or neonates for 9 h to ketamine
anesthesia causes neuroapoptosis in the developing brain. The current study clarifies the …
anesthesia causes neuroapoptosis in the developing brain. The current study clarifies the …
Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats
RD Sanders, J Xu, Y Shu, A Januszewski… - The Journal of the …, 2009 - pubs.asahq.org
Background Neuroapoptosis is induced by the administration of anesthetic agents to the
young. As alpha2 adrenoceptor signaling plays a trophic role during development and is …
young. As alpha2 adrenoceptor signaling plays a trophic role during development and is …
Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice
M Satomoto, Y Satoh, K Terui, H Miyao… - The Journal of the …, 2009 - pubs.asahq.org
Background Neonatal exposure to anesthetics that block N-methyl-D-aspartate receptors
and/or hyperactivate gamma-aminobutyric acid type A receptor has been shown to cause …
and/or hyperactivate gamma-aminobutyric acid type A receptor has been shown to cause …
Anesthesia and cognitive performance in children: no evidence for a causal relationship
Recent findings of an association between anesthesia administration in the first three years
of life and later learning disabilities have created concerns that anesthesia has neurotoxic …
of life and later learning disabilities have created concerns that anesthesia has neurotoxic …
Isoflurane‐induced apoptosis of oligodendrocytes in the neonatal primate brain
Objective: Previously we reported that exposure of 6‐day‐old (P6) rhesus macaques to
isoflurane for 5 hours triggers a robust neuroapoptosis response in developing brain. We …
isoflurane for 5 hours triggers a robust neuroapoptosis response in developing brain. We …