Dipeptidylpeptidase-4 inhibitors (gliptins) focus on drug-drug interactions
AJ Scheen - Clinical pharmacokinetics, 2010 - Springer
Patients with type 2 diabetes mellitus (T2DM) are generally treated with many
pharmacological compounds and are exposed to a high risk of drug-drug interactions …
pharmacological compounds and are exposed to a high risk of drug-drug interactions …
Heterocyclic compounds as dipeptidyl peptidase-IV inhibitors with special emphasis on oxadiazoles as potent anti-diabetic agents
BD Mohammad, MS Baig, N Bhandari, FA Siddiqui… - Molecules, 2022 - mdpi.com
Dipeptidyl peptidase-IV (DPP-IV) inhibitors, often known as gliptins, have been used to treat
type 2 diabetes mellitus (T2DM). They may be combined with other medications as an …
type 2 diabetes mellitus (T2DM). They may be combined with other medications as an …
Tolerability of dipeptidyl peptidase-4 inhibitors: a review
KR Richard, JS Shelburne, JK Kirk - Clinical therapeutics, 2011 - Elsevier
BACKGROUND: Oral glucose-lowering agents are used to treat patients with type 2
diabetes mellitus (T2DM). Most patients require multiple agents to maintain glycemic targets …
diabetes mellitus (T2DM). Most patients require multiple agents to maintain glycemic targets …
DPP-4 inhibitors: focus on safety
SH Tella, MS Rendell - Expert opinion on drug safety, 2015 - Taylor & Francis
Introduction: Dipeptidyl peptidase inhibitors (DPP-4-i) are highly selective inhibitors of the
enzyme DPP-4. They act by increasing levels of incretin hormones, which have potent …
enzyme DPP-4. They act by increasing levels of incretin hormones, which have potent …
Novel univariate spectrophotometric determination of the recently released solid dosage form comprising dapagliflozin and saxagliptin via factorized response spectra …
Dapagliflozin (DPF) and saxagliptin (SXG) are currently co-formulated in a tablet dosage
form which is prescribed to improve glycemic control. The absorption spectra of DPF and …
form which is prescribed to improve glycemic control. The absorption spectra of DPF and …
Rapid generation of novel benzoic acid–based xanthine derivatives as highly potent, selective and long acting DPP-4 inhibitors: scaffold-hopping and prodrug study
Q Li, L Meng, S Zhou, X Deng, N Wang, Y Ji… - European Journal of …, 2019 - Elsevier
A series of novel xanthine derivatives 2a-l incorporating benzoic acid moieties were rapidly
generated by using strategy of scaffold-hopping from our previously reported scaffold uracil …
generated by using strategy of scaffold-hopping from our previously reported scaffold uracil …
Design, synthesis and biological evaluation of Imidazo [1, 2‐a] pyridine derivatives as novel DPP‐4 inhibitors
Q Li, M Zhou, L Han, Q Cao, X Wang… - Chemical biology & …, 2015 - Wiley Online Library
A new series of DPP‐4 inhibitors with imidazo [1, 2‐a] pyridine scaffold were designed by
exploiting scaffold hopping strategy and docking study. Based on docking binding model …
exploiting scaffold hopping strategy and docking study. Based on docking binding model …
Discovery of triazole-based uracil derivatives bearing amide moieties as novel dipeptidyl peptidase-IV inhibitors
X Deng, L Han, J Zhou, H Zhang, Q Li - Bioorganic Chemistry, 2017 - Elsevier
Abstract Dipeptidyl peptidase-IV (DPP-4) is a validated target for T2DM treatment. We
previously reported a novel series of triazole-based uracil derivatives bearing aliphatic …
previously reported a novel series of triazole-based uracil derivatives bearing aliphatic …
Identification of novel uracil derivatives incorporating benzoic acid moieties as highly potent Dipeptidyl Peptidase-IV inhibitors
J Huang, X Deng, S Zhou, N Wang, Y Qin… - Bioorganic & Medicinal …, 2019 - Elsevier
Abstract Dipeptidyl Peptidase-IV (DPP-4) is a validated therapeutic target for type 2
diabetes. Aiming to interact with both residues Try629 and Lys554 in S 2′ site, a series of …
diabetes. Aiming to interact with both residues Try629 and Lys554 in S 2′ site, a series of …
Fast and effective identification of the bioactive compounds and their targets from medicinal plants via computational chemical biology approach
The potential drug target database (PDTD) was searched by the TarFisDock server, a
reverse docking approach, to identify putative targets for a collection of 19 natural products …
reverse docking approach, to identify putative targets for a collection of 19 natural products …