Biologically-based mathematical modeling of tumor vasculature and angiogenesis via time-resolved imaging data
Simple Summary The recruitment of new vasculature via angiogenesis is a critical
component of tumor development, which fundamentally influences tumor growth and …
component of tumor development, which fundamentally influences tumor growth and …
Systems biology of angiogenesis signaling: Computational models and omics
Angiogenesis is a highly regulated multiscale process that involves a plethora of cells, their
cellular signal transduction, activation, proliferation, differentiation, as well as their …
cellular signal transduction, activation, proliferation, differentiation, as well as their …
Self-organized and directed branching results in optimal coverage in developing dermal lymphatic networks
MC Uçar, E Hannezo, E Tiilikainen, I Liaqat… - Nature …, 2023 - nature.com
Branching morphogenesis is a ubiquitous process that gives rise to high exchange surfaces
in the vasculature and epithelial organs. Lymphatic capillaries form branched networks …
in the vasculature and epithelial organs. Lymphatic capillaries form branched networks …
Combined computational modeling and experimental study of the biomechanical mechanisms of platelet-driven contraction of fibrin clots
While blood clot formation has been relatively well studied, little is known about the
mechanisms underlying the subsequent structural and mechanical clot remodeling called …
mechanisms underlying the subsequent structural and mechanical clot remodeling called …
Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist
The extracellular matrix (ECM) is a highly complex structure through which biochemical and
mechanical signals are transmitted. In processes of cell migration, the ECM also acts as a …
mechanical signals are transmitted. In processes of cell migration, the ECM also acts as a …
Matrix stiffness regulates Notch signaling activity in endothelial cells
M Kretschmer, R Mamistvalov… - Journal of Cell …, 2023 - journals.biologists.com
Notch signaling is critical for many developmental and disease-related processes. It is
widely accepted that Notch has a mechanotransduction module that regulates receptor …
widely accepted that Notch has a mechanotransduction module that regulates receptor …
Topological data analysis distinguishes parameter regimes in the Anderson-Chaplain model of angiogenesis
Angiogenesis is the process by which blood vessels form from pre-existing vessels. It plays
a key role in many biological processes, including embryonic development and wound …
a key role in many biological processes, including embryonic development and wound …
Optimal mechanical interactions direct multicellular network formation on elastic substrates
PS Noerr, JE Zamora Alvarado… - Proceedings of the …, 2023 - National Acad Sciences
Cells self-organize into functional, ordered structures during tissue morphogenesis, a
process that is evocative of colloidal self-assembly into engineered soft materials …
process that is evocative of colloidal self-assembly into engineered soft materials …
Computational modeling of angiogenesis: The importance of cell rearrangements during vascular growth
Angiogenesis is the process wherein endothelial cells (ECs) form sprouts that elongate from
the pre‐existing vasculature to create new vascular networks. In addition to its essential role …
the pre‐existing vasculature to create new vascular networks. In addition to its essential role …
On the role of mechanical signals on sprouting angiogenesis through computer modeling approaches
T Abdalrahman, S Checa - Biomechanics and modeling in …, 2022 - Springer
Sprouting angiogenesis, the formation of new vessels from preexisting vasculature, is an
essential process in the regeneration of new tissues as well as in the development of some …
essential process in the regeneration of new tissues as well as in the development of some …