The role of epigenetics, bacterial and host factors in progression of Mycobacterium tuberculosis infection
Tuberculosis (TB) infection caused by Mycobacterium tuberculosis (Mtb) is still a persistent
global health problem, particularly in developing countries. The World Health Organization …
global health problem, particularly in developing countries. The World Health Organization …
[HTML][HTML] Viral persistence and chronicity in hepatitis C virus infection: role of T-cell apoptosis, senescence and exhaustion
Hepatitis C virus (HCV) represents a challenging global health threat to~ 200 million
infected individuals. Clinical data suggest that only~ 10–15% of acutely HCV-infected …
infected individuals. Clinical data suggest that only~ 10–15% of acutely HCV-infected …
[HTML][HTML] Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal …
Mucosal-associated invariant T (MAIT) cells, defined as CD161++ TCR iVα7. 2+ T cells, play
an important role in the innate defense against bacterial infections, and their functionality is …
an important role in the innate defense against bacterial infections, and their functionality is …
[HTML][HTML] PD-1 Expression and Cytokine Secretion Profiles of Mycobacterium tuberculosis-Specific CD4+ T-Cell Subsets; Potential Correlates of Containment in HIV …
KM Pollock, DJ Montamat-Sicotte, L Grass, GS Cooke… - PloS one, 2016 - journals.plos.org
HIV co-infection is an important risk factor for tuberculosis (TB) providing a powerful model in
which to dissect out defective, protective and dysfunctional Mycobacterium tuberculosis …
which to dissect out defective, protective and dysfunctional Mycobacterium tuberculosis …
[HTML][HTML] Plasma CXCL8 and MCP-1 as surrogate plasma biomarkers of latent tuberculosis infection among household contacts–A cross-sectional study
ST Selvavinayagam, B Aswathy, YK Yong… - PLOS Global Public …, 2023 - journals.plos.org
Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current
WHO vision of End Tuberculosis Strategy. The study investigates whether detecting plasma …
WHO vision of End Tuberculosis Strategy. The study investigates whether detecting plasma …
[HTML][HTML] CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell …
R Correa-Rocha, J Lopez-Abente, C Gutierrez… - PLoS …, 2018 - journals.plos.org
In our work, we analyzed the role of the CD100/CD72 and PD-1/PD-L1 axes in immune
response dysfunction in human immunodeficiency virus (HIV)-1 infection in which high …
response dysfunction in human immunodeficiency virus (HIV)-1 infection in which high …
[HTML][HTML] Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection
ST Selvavinayagam, B Aswathy, YK Yong, A Frederick… - medRxiv, 2023 - ncbi.nlm.nih.gov
Background Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination
in the current WHO vision of End Tuberculosis Strategy. Methods We investigated whether …
in the current WHO vision of End Tuberculosis Strategy. Methods We investigated whether …
Increased levels of miR-155 are related to higher T-cell activation in the peripheral blood of patients with chronic hepatitis B
J Fang, L Zhuge, H Rao, S Huang, L Jin… - Genetic testing and …, 2019 - liebertpub.com
Objectives: MicroRNA-155 (miR-155) is an important regulator of immune responses in
humans. However, its role in T-cell activation in hepatitis B virus (HBV) infection remains …
humans. However, its role in T-cell activation in hepatitis B virus (HBV) infection remains …
Recent advances on T-cell exhaustion in malaria infection
EM Shankar, R Vignesh, AP Dash - Medical Microbiology and Immunology, 2018 - Springer
T-cell exhaustion reportedly leads to dysfunctional immune responses of antigen-specific T
cells. Investigations have revealed that T cells expand into functionally defective phenotypes …
cells. Investigations have revealed that T cells expand into functionally defective phenotypes …
[HTML][HTML] Chronic Viral Infection Compromises the Quality of Circulating Mucosal–Associated Invariant T Cells and Follicular T Helper Cells via Expression of Inhibitory …
J Vimali, YK Yong, A Murugesan, HY Tan… - Frontiers in Bioscience …, 2024 - imrpress.com
Background: Chronic viral infection results in impaired immune responses rendering viral
persistence. Here, we compared the quality of T-cell responses among chronic hepatitis B …
persistence. Here, we compared the quality of T-cell responses among chronic hepatitis B …