Mitochondria are the major source of ATP in the cell. Five multi-subunit complexes in the
inner membrane of the organelle are involved in the oxidative phosphorylation required for …

Methylation of riboses at 2′-OH group is one of the most common RNA modifications found
in number of cellular RNAs from almost any species which belong to all three life domains …

Objective: Anxiety disorders are common and often disabling. The goal of this study was to
examine the genetic architecture of anxiety disorders and anxiety symptoms, which are also …

Mitoribosomes are essential for the synthesis and maintenance of bioenergetic proteins.
Here we use cryo-electron microscopy to determine a series of the small mitoribosomal …

Cytoplasmic RNA granules play a central role in mRNA metabolism, but the importance of
mitochondrial RNA granules remains relatively unexplored. We characterized their …

Emerging gene therapy approaches that aim to eliminate pathogenic mutations of
mitochondrial DNA (mtDNA) rely on efficient degradation of linearized mtDNA, but the …

Perturbation of mitochondrial DNA (mtDNA) gene expression can lead to human
pathologies. Therefore, a greater appreciation of the basic mechanisms of mitochondrial …

The ribosome is a structurally and functionally conserved macromolecular machine
universally responsible for catalyzing protein synthesis. Within eukaryotic cells, mitochondria …

Mitochondria play fundamental roles in the regulation of life and death of eukaryotic cells.
They mediate aerobic energy conversion through the oxidative phosphorylation (OXPHOS) …

Ribosome biogenesis requires auxiliary factors to promote folding and assembly of
ribosomal proteins and RNA. Particularly, maturation of the peptidyl transferase center (PTC) …