With the recent FDA approval of the first siRNA‐derived therapeutic, RNA interference
(RNAi)‐mediated gene therapy is undergoing a transition from research to the clinical …

Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …

The discovery of RNA interference, first in plants and Caenorhabditis elegans and later in
mammalian cells, led to the emergence of a transformative view in biomedical research …

Gene therapy is becoming an influential part of the rapidly increasing armamentarium of
biopharmaceuticals for improving health and combating diseases. Currently, three gene …

Inducing destruction of specific mRNA using small interfering RNA (siRNA) is a powerful tool
in analysis of protein function, but its use as a therapeutic modality has been limited by …

Since the evolutionary discovery of RNA interference and its utilization for gene knockdown
in mammalian cell, a remarkable progress has been achieved in small interfering RNA …

RNA therapeutics refers to the use of oligonucleotides to target primarily ribonucleic acids
(RNA) for therapeutic efforts or in research studies to elucidate functions of genes …

Background At present, the entire world is in a war against COVID-19 pandemic which has
gradually led us toward a more compromised “new normal” life. SARS-CoV-2, the …

Microtubule (MT)-based motor proteins, kinesins and dyneins, play important roles in
multiple cellular processes including cell division. In this study, we describe the generation …

In the past 4 years, RNA interference (RNAi) has become widely used as an experimental
tool to analyse the function of mammalian genes, both in vitro and in vivo. By harnessing an …