Reassessing Human Adipose Tissue Adipose tissue can more than double in mass and
then return to baseline. This review discusses the functional roles of human white and brown …

Cardiovascular diseases are the leading cause of death worldwide. Overweight and obesity
are strongly associated with comorbidities such as hypertension and insulin resistance …

White fat stores excess energy, whereas brown and beige fat are thermogenic and dissipate
energy as heat. Thermogenic adipose tissues markedly improve glucose and lipid …

Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …

Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

Many approaches have been used in the effective management of type 2 diabetes mellitus.
A recent paradigm shift has focused on the role of adipose tissues in the development and …

Obesity is a chronic and progressive process affecting whole-body energy balance and is
associated with comorbidity development. In addition to increased fat mass, obesity induces …

The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for
the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR …

Adipose tissue macrophage (ATM) inflammation is involved with meta-inflammation and
pathology of metabolic complications. Here we report that in adipocytes, elevated lactate …