Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the
worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell …

Autophagy as a means of cell killing was first advanced by Clark's phenotypic description of
'Type II autophagic cell death'in 1990. However, this phenomenon later came into question …

The BET family of proteins consists of BRD2, BRD3, BRD4, and BRDt. Each protein contains
two distinct bromodomains (BD1 and BD2). BET family bromodomain inhibitors under …

Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, but
an effective targeted therapy has not been well-established so far. Considering the lack of …

Bromodomain-containing protein 4 (Brd4) plays an important role in mediating the
expression of genes involved in cancers and non-cancer diseases such as inflammatory …

Blocking the interactions between bromodomain and extraterminal (BET) proteins and
acetylated lysines of histones by small molecules has important implications for the …

Epigenetic factor Brd4 has emerged as a key regulator of cancer cell proliferation. Targeted
inhibition of Brd4 suppresses growth and induces apoptosis of various cancer cells. In …

Bromodomain-containing protein 4 (BRD4) and histone deacetylases (HDAC) are both
attractive epigenetic targets in cancer and other chronic diseases. Based on the integrated …

Radix astragali, a medicinal material for tonifying Chinese Qi, has widely been used for the
treatment of Kidney disease in China and East Asia, especially in reducing the apoptosis of …

Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) is a rate-limiting enzyme that catalyzes the
kynurenine (Kyn) pathway of tryptophan metabolism in the first step, and the kynurenine …