The chemistry of 1, 3, 4-thiadiazole is one of the most interesting scaffolds for synthesizing
new drug molecules due to their numerous pharmacological activities. Several modifications …

The bioisosteres of 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles are well-known
pharmacophores for many medicinally important drugs. Throughout the past 10 years, 1, 3, 4 …

Introduction Inflammation is a fundamental response of the immune system during tissue
damage or pathogen infection to protect and maintain tissue homeostasis. However …

Despite rapid advances in drug accessibility for diagnosis and treatment, breast cancer
remains a common malignancy among women across the world due to the inadequacy of …

1, 3, 4-thiadiazole is a five-membered aromatic heterocycle containing two nitrogen atoms
and one sulfur atom. As a privileged scaffold, it has its unique chemical properties and …

A series of novel hybrids comprising of 1, 3, 4-oxadiazole/thiadiazole and 1, 2, 4-triazole
tethered to 5, 6-diphenyl-1, 2, 4-triazin-3 (2H)-one were designed, synthesised and …

The theoretical calculations of the 2, 4-dimethoxy-1, 3, 5-triazine (DMT) molecule were
performed with the help of density functional theory (DFT) calculations using 6-311++ G (d …

Background: This review summarizes data on heterocyclic systems with thiadiazole and
thiazole fragments in molecules as promising antimicrobial agents. Introduction: Thiadiazole …

This article presents the results of spectroscopic studies of two compounds from the 1, 3, 4-
thiadiazole group, that is, 4-(5-methyl-1, 3, 4-thiadiazole-2-yl) benzene-1, 3-diol (C1) and 4 …

Alkyl phenylcarbamodithioates were reacted with hydrazonoyl bromide 1a, b in ethanol
containing a catalytic amount of triethylamine solution to afford and 1, 3, 4-thiadiazole …