Multipotent retinal progenitors undergo a varied number of divisions to produce clones of
heterogeneous sizes and cell types. We describe the transition from a proliferating …

Over the last decade, the use of the zebrafish as a genetic model has moved beyond the
proof-of-concept for the analysis of vertebrate embryonic development to demonstrated …

In response to cardiac damage, a mesothelial tissue layer enveloping the heart called the
epicardium is activated to proliferate and accumulate at the injury site. Recent studies have …

Adult mammalian cardiomyocytes have little capacity to proliferate in response to injury, a
deficiency that underlies the poor regenerative ability of human hearts after myocardial …

Sharply delineated domains of cell types arise in developing tissues under instruction of
inductive signal (morphogen) gradients, which specify distinct cell fates at different signal …

The timing of cell cycle exit and temporal changes in the developmental competence of
precursor cells are key components for the establishment of the normal complement of cell …

In vertebrates, midline-derived sonic hedgehog and nodal are crucial for the initial proximal-
distal patterning of the eye. The establishment of the distal optic stalk is in turn a prerequisite …

The mature, functional, and healthy eye is generated by the coordinated regulatory
interaction of numerous and diverse developing tissues. The neural retina of the eye must …

The ciliary marginal zone (CMZ) is a circumferential ring of cells found at the extreme
periphery of the maturing and mature neural retina that consists of retinal stem and …

The retinas of teleost fish have long been of interest to developmental neurobiologists for
their persistent plasticity during growth, life history changes, and response to injury. Because …