The zebrafish model is the only available high-throughput vertebrate assessment system,
and it is uniquely suited for studies of in vivo cell biology. A sequenced and annotated …

The medaka fish Tol2 element is an autonomous transposon that encodes a fully functional
transposase. The transposase protein can catalyze transposition of a transposon construct …

To connect human biology to fish biomedical models, we sequenced the genome of spotted
gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome …

We developed a new way to engineer complex proteins toward multidimensional
specifications using a simple, yet scalable, directed evolution strategy. By robotically picking …

Cell-fate transitions involve the integration of genomic information encoded by regulatory
elements, such as enhancers, with the cellular environment,. However, identification of …

We performed whole-genome sequencing (WGS) of 208 genomes from 53 families affected
by simplex autism. For the majority of these families, no copy-number variant (CNV) or …

Transgenesis is an important tool for assessing gene function. In zebrafish, transgenesis has
suffered from three problems: the labor of building complex expression constructs using …

The identification of active neurons and circuits in vivo is a fundamental challenge in
understanding the neural basis of behavior. Genetically encoded calcium (Ca2+) indicators …

Understanding brain function requires monitoring and interpreting the activity of large
networks of neurons during behavior. Advances in recording technology are greatly …

While mammals have a limited capacity to repair bone defects, zebrafish can completely
regenerate amputated bony structures of their fins. Fin regeneration is dependent on …