Toll‐like receptors (TLRs): structure, functions, signaling, and role of their polymorphisms in colorectal cancer susceptibility

AS Sameer, S Nissar - BioMed Research International, 2021 - Wiley Online Library
Toll‐like receptors (TLRs) are the important mediators of inflammatory pathways in the gut
which play a major role in mediating the immune responses towards a wide variety of …

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

E Connell, G Le Gall, MG Pontifex, S Sami… - Molecular …, 2022 - Springer
A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

[HTML][HTML] Mechanisms of action of probiotics

J Plaza-Diaz, FJ Ruiz-Ojeda, M Gil-Campos, A Gil - Advances in nutrition, 2019 - Elsevier
Probiotics are living microorganisms that confer health benefits to the host when
administered in adequate amounts; however, dead bacteria and their components can also …

[HTML][HTML] The vagus nerve at the interface of the microbiota-gut-brain axis

B Bonaz, T Bazin, S Pellissier - Frontiers in neuroscience, 2018 - frontiersin.org
The microbiota, the gut, and the brain communicate through the microbiota-gut-brain axis in
a bidirectional way that involves the autonomic nervous system. The vagus nerve (VN), the …

Modulatory effects of probiotics during pathogenic infections with emphasis on immune regulation

A Raheem, L Liang, G Zhang, S Cui - Frontiers in immunology, 2021 - frontiersin.org
In order to inhibit pathogenic complications and to enhance animal and poultry growth,
antibiotics have been extensively used for many years. Antibiotics applications not only …

[HTML][HTML] Inflammatory bowel disease: pathogenesis

YZ Zhang, YY Li - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is
characterized by chronic relapsing intestinal inflammation. It has been a worldwide health …

[HTML][HTML] In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection

S Bartfeld, T Bayram, M van de Wetering, M Huch… - Gastroenterology, 2015 - Elsevier
Background & Aims We previously established long-term, 3-dimensional culture of
organoids from mouse tissues (intestine, stomach, pancreas, and liver) and human intestine …

Radiation-induced fibrosis: mechanisms and implications for therapy

JM Straub, J New, CD Hamilton, C Lominska… - Journal of cancer …, 2015 - Springer
Purpose Radiation-induced fibrosis (RIF) is a long-term side effect of external beam
radiation therapy for the treatment of cancer. It results in a multitude of symptoms that …

Probiotic mechanisms of action

M Bermudez-Brito, J Plaza-Díaz… - Annals of Nutrition and …, 2012 - karger.com
Probiotics are live microorganisms that provide health benefits to the host when ingested in
adequate amounts. The strains most frequently used as probiotics include lactic acid …

Antibiotics in early life alter the murine colonic microbiome and adiposity

I Cho, S Yamanishi, L Cox, BA Methé, J Zavadil, K Li… - Nature, 2012 - nature.com
Antibiotics administered in low doses have been widely used as growth promoters in the
agricultural industry since the 1950s, yet the mechanisms for this effect are unclear. Because …