[HTML][HTML] Blocking NMDAR disrupts spike timing and decouples monkey prefrontal circuits: implications for activity-dependent disconnection in schizophrenia
We employed multi-electrode array recording to evaluate the influence of NMDA receptors
(NMDAR) on spike-timing dynamics in prefrontal networks of monkeys as they performed a …
(NMDAR) on spike-timing dynamics in prefrontal networks of monkeys as they performed a …
Ketamine alters lateral prefrontal oscillations in a rule-based working memory task
Acute administration of N-methyl-D-aspartate receptor (NMDAR) antagonists in healthy
humans and animals produces working memory deficits similar to those observed in …
humans and animals produces working memory deficits similar to those observed in …
Ketamine-induced changes in the signal and noise of rule representation in working memory by lateral prefrontal neurons
L Ma, K Skoblenick, JK Seamans… - Journal of …, 2015 - Soc Neuroscience
Working memory dysfunction is an especially debilitating symptom in schizophrenia. The
NMDA antagonist ketamine has been successfully used to model working memory deficits in …
NMDA antagonist ketamine has been successfully used to model working memory deficits in …
Cholinergic overstimulation attenuates rule selectivity in macaque prefrontal cortex
Acetylcholine is released in the prefrontal cortex (PFC) and is a key modulator of cognitive
performance in primates. Cholinergic stimulation has been shown to have beneficial effects …
performance in primates. Cholinergic stimulation has been shown to have beneficial effects …
NMDA receptors enhance the fidelity of synaptic integration
C Li, AT Gulledge - Eneuro, 2021 - eneuro.org
Excitatory synaptic transmission in many neurons is mediated by two coexpressed
ionotropic glutamate receptor subtypes, AMPA and NMDA receptors, that differ in kinetics …
ionotropic glutamate receptor subtypes, AMPA and NMDA receptors, that differ in kinetics …
[HTML][HTML] Conflict resolution as near-threshold decision-making: a spiking neural circuit model with two-stage competition for antisaccadic task
Automatic responses enable us to react quickly and effortlessly, but they often need to be
inhibited so that an alternative, voluntary action can take place. To investigate the brain …
inhibited so that an alternative, voluntary action can take place. To investigate the brain …
Effects of ketamine on brain function during response inhibition
M Steffens, C Neumann, AM Kasparbauer… - …, 2018 - Springer
Introduction The uncompetitive N-methyl-D-aspartate (NMDA) receptor (NMDAR) antagonist
ketamine has been proposed to model symptoms of psychosis. Inhibitory deficits in the …
ketamine has been proposed to model symptoms of psychosis. Inhibitory deficits in the …
Ketamine alters outcome-related local field potentials in monkey prefrontal cortex
A subanesthetic dose of the noncompetitive N-methyl-d-aspartate receptor antagonist
ketamine is known to induce a schizophrenia-like phenotype in humans and nonhuman …
ketamine is known to induce a schizophrenia-like phenotype in humans and nonhuman …
[HTML][HTML] Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making
M Oemisch, H Seo - Elife, 2024 - elifesciences.org
The discovery of rapid-acting antidepressant, ketamine has opened a pathway to a new
generation of treatments for depression, and inspired neuroscientific investigation based on …
generation of treatments for depression, and inspired neuroscientific investigation based on …
Contribution of ionotropic glutamatergic receptors to excitability and attentional signals in macaque frontal eye field
M Dasilva, C Brandt, M Alwin Gieselmann… - Cerebral …, 2021 - academic.oup.com
Top-down attention, controlled by frontal cortical areas, is a key component of cognitive
operations. How different neurotransmitters and neuromodulators flexibly change the …
operations. How different neurotransmitters and neuromodulators flexibly change the …