The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

Tuberculosis (TB) remains one of the leading public health problems worldwide. Declared
as a global emergency in 1993 by the WHO, its control is hampered by the emergence of …

Tuberculosis (TB) chemotherapy started in the 1930s with the discovery by Domagk and
colleagues of the anti‐TB activity of sulfonamides. Since these compounds were very toxic …

Molecular typing has revolutionized epidemiological studies of infectious diseases,
including those of a mycobacterial etiology. With the advent of fingerprinting techniques …

Isoniazid (INH) is one of the most efficient drugs for the treatment of Mycobacterium
tuberculosis infections. Despite its rather simple chemical structure, the mechanism by which …

Tuberculosis (TB) is a major infectious disease killing nearly two million people, mostly in
developing countries, every year. The increasing incidence of resistance of Mycobacterium …

Recent rises in incident tuberculosis (TB) cases in Paraguay and the increasing
concentration of TB within prisons highlight the urgency of targeting strategies to interrupt …

Isoniazid, administered as part of combination antituberculosis therapy, is responsible for
most of the early bactericidal activity (EBA) of the regimen. However, the emergence of …

Vietnam is ranked 13th among the WHO list of 22 high-burden countries, based upon
estimated total number of tuberculosis cases. Despite having a model national tuberculosis …

Herein a series of 4-aminoquinolines were synthesized in an attempt to optimize and study
the structural features related to LABIO-17 biological activity, a Mycobacterium tuberculosis …