Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use

GP Fadini, D Losordo, S Dimmeler - Circulation research, 2012 - Am Heart Assoc
Diverse subsets of endothelial progenitor cells (EPCs) are used for the treatment of ischemic
diseases in clinical trials, and circulating EPCs levels are considered as biomarkers for …

Platelets, inflammation and atherosclerosis

S Lindemann, B Krämer, P Seizer… - Journal of thrombosis …, 2007 - Wiley Online Library
An expanding body of evidence continues to build on the role of platelets as initial actors in
the development of atherosclerotic lesions. Platelets bind to leukocytes and endothelial …

Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms

SV de Kreutzenberg, G Ceolotto, I Papparella… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Sirtuins (SIRTs) are NAD+-dependent deacetylases that regulate metabolism
and life span. We used peripheral blood mononuclear cells (PBMCs) to determine ex vivo …

Endothelial progenitor cells in neovascularization of infarcted myocardium

K Jujo, M Ii, DW Losordo - Journal of molecular and cellular cardiology, 2008 - Elsevier
Historically, revascularization of ischemic tissue was believed to occur through the migration
and proliferation of endothelial cells in nearby tissues; however, evidence accumulated in …

Technical notes on endothelial progenitor cells: ways to escape from the knowledge plateau

GP Fadini, I Baesso, M Albiero, S Sartore, C Agostini… - Atherosclerosis, 2008 - Elsevier
In the last 10 years an increasing interest has been devoted to the study of endothelial
progenitor cells (EPCs), a subtype of immature cells involved in endothelial repair and …

Circulating stem cells and cardiovascular outcomes: from basic science to the clinic

GP Fadini, A Mehta, DS Dhindsa… - European heart …, 2020 - academic.oup.com
The cardiovascular and haematopoietic systems have fundamental inter-relationships
during development, as well as in health and disease of the adult organism. Although …

Endothelial progenitor cells in the natural history of atherosclerosis

GP Fadini, C Agostini, S Sartore, A Avogaro - Atherosclerosis, 2007 - Elsevier
Atherosclerotic diseases are responsible for a significant part of morbidity and mortality in
western countries. According to the classical views, atherosclerotic lesions develop as the …

Gender differences in endothelial progenitor cells and cardiovascular risk profile: the role of female estrogens

GP Fadini, S de Kreutzenberg, M Albiero… - … , and vascular biology, 2008 - Am Heart Assoc
Objective—Endothelial progenitor cells (EPCs) participate in vascular homeostasis and
angiogenesis. The aim of the present study was to explore EPC number and function in …

The promise of cell-based therapies for diabetic complications: challenges and solutions

YPR Jarajapu, MB Grant - Circulation research, 2010 - Am Heart Assoc
The discovery of endothelial progenitor cells (EPCs) in human peripheral blood advanced
the field of cell-based therapeutics for many pathological conditions. Despite the lack of …

Circulating endothelial progenitor cells, endothelial function, carotid intima–media thickness and circulating markers of endothelial dysfunction in people with type 1 …

L Sibal, A Aldibbiat, SC Agarwal, G Mitchell, C Oates… - Diabetologia, 2009 - Springer
Aims/hypothesis Type 1 diabetes is associated with premature arterial disease. Bone-
marrow derived, circulating endothelial progenitor cells (EPCs) are believed to contribute to …