Biological membranes and membrane proteins, responsible for numerous exciting
biological processes, present one of the paramount challenges in biophysics today …

► Lipid bicelles have matured to full membership in the club of lipid phases.► Numerous
techniques have elucidated the character traits of bicelles.► Bicelles are exemplary citizens …

Analysis of the literature involving computational modeling of diseases and drug design with
the aid of experimental spectroscopic techniques reveals that this specific combination of …

One of the biggest challenges in solid-state NMR studies of membrane proteins is to obtain
a homogeneous natively folded sample giving high spectral resolution sufficient for …

Rhomboids comprise a broad family of intramembrane serine proteases that are found in a
wide range of organisms and participate in a diverse array of biological processes. High …

The biochemical processes of living cells involve a numerous series of reactions that work
with exceptional specificity and efficiency. The tight control of this intricate reaction network …

About 8000 genes encode membrane proteins in the human genome. The information about
their druggability will be very useful to facilitate drug discovery and development. The main …

Attempts at substituting detergents with other surfactants for handling membrane proteins
(MPs) in aqueous solutions have a long history. They are based on three main incentives:(i) …

Oligomerization of hepatitis C viral envelope proteins E1 and E2 is essential to virus fusion
and assembly. Although interactions within the transmembrane (TM) domains of these …

Pulsed-field-gradient nuclear magnetic resonance (PFG-NMR) is used to obtain the true
hydrodynamic size of complexes of peptides with sodium dodecyl sulfate SDS micelles. The …