Non-invasive biomarkers for early detection of breast cancer

J Li, X Guan, Z Fan, LM Ching, Y Li, X Wang, WM Cao… - Cancers, 2020 - mdpi.com
Simple Summary Early diagnosis of breast cancer greatly increases the chance of cure and
survival from the disease. The mammogram is widely used for early detection of breast …

Chemometrics in metabolomics—a review in human disease diagnosis

R Madsen, T Lundstedt, J Trygg - Analytica chimica acta, 2010 - Elsevier
Metabolomics is a post genomic research field concerned with developing methods for
analysis of low molecular weight compounds in biological systems, such as cells, organs or …

Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing

MC Lucas, LP Pryszcz, R Medina, I Milenkovic… - Nature …, 2024 - nature.com
Transfer RNAs (tRNAs) play a central role in protein translation. Studying them has been
difficult in part because a simple method to simultaneously quantify their abundance and …

Elemental formula annotation of polar and lipophilic metabolites using 13C, 15N and 34S isotope labelling, in combination with high‐resolution mass spectrometry

P Giavalisco, Y Li, A Matthes, A Eckhardt… - The Plant …, 2011 - Wiley Online Library
The unbiased and comprehensive analysis of metabolites in any organism presents a major
challenge if proper peak annotation and unambiguous assignment of the biological origin of …

Cancer metabolomic markers in urine: evidence, techniques and recommendations

SS Dinges, A Hohm, LA Vandergrift, J Nowak… - Nature reviews …, 2019 - nature.com
Urinary tests have been used as noninvasive, cost-effective tools for screening, diagnosis
and monitoring of diseases since ancient times. As we progress through the 21st century …

Early breast cancer detection using untargeted and targeted metabolomics

Y Wei, P Jasbi, X Shi, C Turner, J Hrovat… - Journal of proteome …, 2021 - ACS Publications
Breast cancer (BC) is a common cause of morbidity and mortality, particularly in women.
Moreover, the discovery of diagnostic biomarkers for early BC remains a challenging task …

Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review

A Roux, D Lison, C Junot, JF Heilier - Clinical biochemistry, 2011 - Elsevier
The metabolome is the set of small molecular mass organic compounds found in a given
biological media. It includes all organic substances naturally occurring from the metabolism …

Urine metabolite analysis offers potential early diagnosis of ovarian and breast cancers

CM Slupsky, H Steed, TH Wells, K Dabbs… - Clinical cancer …, 2010 - AACR
Purpose: Metabolomics is a new, rapidly expanding field dedicated to the global study of
metabolites in biological systems. In this article metabolomics is applied to find urinary …

Metabolomic fingerprinting: challenges and opportunities

AK Kosmides, K Kamisoglu, SE Calvano… - Critical Reviews™ in …, 2013 - dl.begellhouse.com
Systems biology has primarily focused on studying genomics, transcriptomics, and
proteomics and their dynamic interactions. These, however, represent only the potential for a …

Review of mass spectrometry–based metabolomics in cancer research

DB Liesenfeld, N Habermann, RW Owen… - … , biomarkers & prevention, 2013 - AACR
Metabolomics, the systematic investigation of all metabolites present within a biologic
system, is used in biomarker development for many human diseases, including cancer. In …