In vitro cell cultures are crucial research tools for modeling human development and
diseases. Although the conventional monolayer cell cultures have been widely used in the …

Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells
to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key …

Engineering organ-specific tissues for therapeutic applications is a grand challenge,
requiring the fabrication and maintenance of densely cellular constructs composed of~ 108 …

The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Accumulating evidence demonstrates important roles for metabolism in cell fate
determination. However, it is a challenge to assess metabolism at a spatial resolution that …

There is an alarming global increase in the incidence of end-stage kidney disease, for which
early biomarkers and effective treatment options are lacking. Largely based on the histology …

The limitations of traditional two-dimensional (2D) cultures and animal testing, when it
comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug …

Congenital anomalies of the kidneys and urinary tracts (CAKUT) are disorders caused by
defects in the development of the kidneys and their outflow tracts. The formation of the …

In the past decade, the term organoid has moved from obscurity to common use to describe
a 3D in vitro cellular model of a tissue that recapitulates structural and functional elements of …

Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular
cells within human cardiac organoids (hCOs) enhance their maturation, force of contraction …