Major depressive disorder (MDD) is a prevalent psychiatric disease that involves
malfunctions of different cell types in the brain. Accumulating studies started to reveal that …

Despite decades of intensive research, the biological mechanisms that causally underlie
depression are still unclear, and therefore the development of novel effective antidepressant …

Data from clinical and preclinical studies indicate that immune dysregulation, specifically of
inflammatory processes, is associated with symptoms of major depressive disorder (MDD) …

There is a growing emphasis on the relationship between the complexity and diversity of the
microorganisms that inhabit our gut (human gastrointestinal microbiota) and health/disease …

Therapeutic glucocorticoids have been widely used in rheumatic diseases since they
became available over 60 years ago. Despite the advent of more specific biologic therapies …

Psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD) and
schizophrenia, affect a significant percentage of the world population. These disorders are …

Major depression is a prevalent illness that increases the risk of several neurological
conditions. These include stroke, cardiovascular disease, and dementia including …

Over the past three decades, an intricate interaction between immune activation, release of
pro-inflammatory cytokines and changes in brain circuits related to mood and behavior has …

The population of aged individuals is increasing worldwide and this has significant health
and socio-economic implications. Clinical and experimental studies on aging have …

Recent years have witnessed a revolution in our understanding of microglia biology,
including their major role in the etiology and pathogenesis of neurodegenerative diseases …