Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways
involved in numerous physiological processes (eg, vasodilation, neurotransmission …

Well over 2 decades have passed since the endothelium-derived relaxation factor was
reported to be the gaseous molecule nitric oxide (NO). Although soluble guanylyl cyclase …

During the 1980s, the free radical, nitric oxide (NO), was discovered to be a crucial
signalling molecule, with wide‐ranging functions in the cardiovascular, nervous and immune …

BACKGROUND: Endothelial injury plays a critical role in coronary artery disease (CAD), but
the assessment of this injury has been problematical. Recently, it has been shown in vitro …

Increased platelet activation is recognized in patients with sickle cell disease (SCD), but its
pathogenesis and clinical relevance remain uncertain. Pulmonary arterial hypertension …

Adiponectin is a major adipocyte-secreted adipokine abundantly present in the circulation
as three distinct oligomeric complexes. In addition to its role as an insulin sensitizer …

Non-heme iron nitrosyls have been recognized by chemists for well over 100 years, but their
place in biology was given serious attention only after the discovery of the biological role of …

Although the short-term vasodilatory properties of or-ganic nitrates are potent and well
known, a number of vascular and extravascular changes have been shown to compromise …

The signaling molecule nitric oxide (NO), first described as endothelium-derived relaxing
factor (EDRF), acts as physiological activator of NO-sensitive guanylyl cyclase (NO-GC) in …

Nitric oxide (NO) exerts important vasodilatory, antiplatelet, antioxidant, antiadhesive, and
antiproliferative effects. Although endothelium derived NO has been shown to be of prime …