Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB,
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …

Sickle cell pain includes 3 types: acute recurrent painful crises, chronic pain syndromes, and
neuropathic pain. The acute painful crisis is the hallmark of the disease and the most …

Pain in sickle cell disease (SCD) is associated with increased morbidity, mortality, and high
health care costs. Although episodic acute pain is the hallmark of this disorder, there is an …

Sickle cell disease and its variants constitute the most common inherited blood disorders
affecting millions of individuals worldwide. Significant information regarding the nature of the …

Despite frequent episodes of severe recurrent pain in sickle cell disease (SCD), sensory
pain in outpatient adults with SCD lacks sufficient characterization. Furthermore, pivotal …

New epidemiological findings recast pain in sickle-cell disease (SCD) as being more often a
chronic manifestation than was previously thought, although acute pain is still the hallmark …

Objective This study aimed to quantify the indirect costs of sickle cell disease in the United
States. Methods Adult patients from a sickle cell disease clinic at an urban academic …

Objectives: Research-derived evidence about the impact of sickle cell disease (SCD) on the
lives of affected adults is lacking. We conducted formative research to provide the basis for a …

We report results of a pilot study of high‐dose vitamin D in sickle cell disease (SCD).
Subjects were given a 6‐week course of oral high‐dose cholecalciferol (4000–100 000 IU …

Objective Somatic symptoms have been extensively studied in primary care, but infrequently
in diseases causing pain in multiple sites. We therefore examined the impact of somatic …