Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Cisplatin (CP) is a well-known chemotherapeutic agent with excellent clinical effects. The
anti-tumor activity of CP has been demonstrated in different cancers such as breast, cervical …

The mechanisms underlying acute kidney injury (AKI) and chronic kidney disease (CKD)
progression include interstitial inflammation, cellular senescence, and oxidative stress (OS) …

The development of oral cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors, including
palbociclib, ribociclib, and abemaciclib, has revolutionized the treatment landscape for …

Ischemic acute kidney injury (AKI) has always been a hot and difficult research topic in the
field of renal diseases. This study aims to illustrate the safe warm ischemia time of kidney …

A multitude of disease and therapy related factors drive the frequent development of kidney
disorders in cancer patients. Along with chemotherapy, the newer targeted therapeutics can …

Acute kidney injury (AKI) is a common clinical condition associated with diverse etiologies
and abrupt loss of renal function. In patients with sepsis, rhabdomyolysis, cancer, and …

Background: The synthetic tetra-peptide SS-31 shows promise in alleviating mitochondrial
dysfunction associated with common diseases. However, the precise pharmacological basis …

Life expectancy is increasing worldwide, and by 2050 the proportion of the world's
population over 65 years of age is estimated to surpass 1.5 billion. Kidney aging is …

Objective Energy-intensive kidney reabsorption processes essential for normal whole-body
function are maintained by tubular epithelial cell metabolism. Although tubular metabolism …