The endoplasmic reticulum (ER) is the largest intracellular organelle carrying out a broad
range of important cellular functions including protein biosynthesis, folding, and trafficking …

The gut microbiome is a complex ecosystem of microorganisms and their genetic entities
colonizing the gastrointestinal tract. When in balanced composition, the gut microbiome is in …

Age-related macular degeneration (AMD) is the leading cause of visual impairment in the
aging population with a limited understanding of its pathogenesis and the number of …

The innate immune landscape of the central nervous system (CNS), including the brain and
the retina, consists of different myeloid cell populations with distinct tasks to fulfill. Whereas …

Subretinal fibrosis remains a major obstacle to the management of neovascular age-related
macular degeneration. Choroidal pericytes were found to be a significant source of …

Background Subretinal fibrosis (SF) accounts for vision loss in patients with neovascular age-
related macular degeneration (nAMD) even treated with adequate intravitreal injection of …

Background Macular subretinal fibrosis is the end-stage complication of neovascular age-
related macular degeneration (nAMD). We previously developed a mouse model of two …

Abstract Background Retinal fibrosis affects 40–70% of neovascular age-related macular
degeneration patients. This study investigated the effect of ageing on subretinal fibrosis …

Proper functioning of the neural retina relies on the unique retinal environment regulated by
the blood–retinal barrier (BRB), which restricts the passage of solutes, fluids, and toxic …

Disruption of the extracellular matrix (ECM) and an accumulation of fibrotic lesions within
tissues are two of the distinctive hallmarks of the aging process. Tissue fibroblasts are …