CTNNB1 is the gene that encodes β-catenin which acts as a key player in the Wnt signaling
pathway and regulates cellular homeostasis. Most CTNNB1-related studies have been …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Summary β-Catenin is a central component in the Wnt signaling pathway; its degradation
has been tightly connected to ubiquitylation, but it is rarely examined by loss-of-function …

The excitability of interneurons requires Nav1. 1, the α subunit of the voltage-gated sodium
channel. Nav1. 1 deficiency and mutations reduce interneuron excitability, a major …

Stress is unavoidable and essential to cellular and organismal evolution and failure to adapt
or restore homeostasis can lead to severe diseases or even death. At the cellular level …

Neddylation, a type of protein post-translational modification that links the ubiquitin-like
protein NEDD8 to substrate proteins, can be involved in various significant cellular …

Neddylation, a posttranslational protein modification, refers to the specific conjugation of
NEDD8 to substrates, which is of great significance to various biological processes. Besides …

Canonical Wnt signaling is essential for a plethora of biological processes ranging from
early embryogenesis to aging. Malfunctions of this crucial signaling pathway are associated …

Myelination is essential for neuronal function and health. In peripheral nerves,> 100
causative mutations have been identified that cause Charcot-Marie-Tooth disease, a …

Ischemic stroke (IS) is a complex neurological disease that can lead to severe disability or
even death. Understanding the molecular mechanisms involved in the occurrence and …