Histone variants endow chromatin with unique properties and show a specific genomic
distribution that is regulated by specific deposition and removal machineries. These variants …

Cancerous tumours contain a rare subset of cells with stem‐like properties that are termed
cancer stem cells (CSCs). CSCs are defined by their ability to divide both symmetrically and …

Ability to form cellular aggregations such as tumorspheres and spheroids have been used
as a morphological marker of malignant cancer cells and in particular cancer stem cells …

Various studies demonstrate that long noncoding RNAs (IncRNAs) act as oncogenes or
tumor suppressors in cancer. However, the function of IncRNAs in bladder cancer still …

Genetic loss-of-function studies on development, cancer and somatic cell reprogramming
have suggested that the group of macroH2A histone variants might function through …

Histone variants are chromatin components that replace replication-coupled histones in a
fraction of nucleosomes and confer particular characteristics to chromatin. H2A variants …

Chromatin integrity is key for cell homeostasis and for preventing pathological development.
Alterations in core chromatin components, histone proteins, recently came into the spotlight …

Simple Summary The structural unit of chromatin is the nucleosome that is composed of
DNA wrapped around a core of eight histone proteins. Histone variants can replace …

There is growing evidence of the presence of cancer stem cells in urothelial carcinoma.
Cancer stem cells have the ability to self‐renew and to differentiate into all cell types of the …

Hepatocellular carcinomas (HCC) contain a subpopulation of cancer stem cells (CSCs),
which exhibit stem cell–like features and are responsible for tumor relapse, metastasis, and …