Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …

Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They
support intracellular trafficking, cell division, cellular motility, and other essential cellular …

Eukaryotic cells rely on long-lived microtubules for intracellular transport and as
compression-bearing elements. We considered that long-lived microtubules are acetylated …

Long-lived microtubules endow the eukaryotic cell with long-range transport abilities. While
long-lived microtubules are acetylated on Lys40 of α-tubulin (αK40), acetylation takes place …

Mitochondria are highly dynamic organelles that constantly migrate, fuse, and divide to
regulate their shape, size, number, and bioenergetic function. Mitofusins (Mfn1/2), optic …

Microtubules have important functions ranging from maintenance of cell morphology to
subcellular transport, cellular signaling, cell migration, and formation of cell polarity. At the …

Microtubules are hollow tube-like polymeric structures composed of α, β-tubulin
heterodimers. They play an important role in numerous cellular processes, including …

Acetylation of α-tubulin Lys40 by tubulin acetyltransferase (TAT) is the only known
posttranslational modification in the microtubule lumen. It marks stable microtubules and is …

In animals, maternal diet and environment can influence the health of offspring. Whether and
how maternal dietary choice impacts the nervous system across multiple generations is not …

Axon injury leads to rapid depletion of NAD-biosynthetic enzyme NMNAT2 and high levels
of its substrate, NMN. We proposed a key role for NMN in Wallerian degeneration but …