Importance Heart failure with preserved ejection fraction (HFpEF), defined as HF with an EF
of 50% or higher at diagnosis, affects approximately 3 million people in the US and up to 32 …

Key Points Systemic Light Chain Amyloidosis Immunoglobulin light chain (AL) amyloidosis
is a rare disease that occurs when a plasma cell disorder produces monoclonal light chains …

Abstract Background Low QRS voltages (LQRSVs) are a common electrocardiographic
feature in patients with light chain amyloidosis (AL) and transthyretin amyloidosis (ATTR) …

Amyloid light chain (AL) amyloidosis is a rare, debilitating, often fatal disease. Symptoms of
cardiomyopathy are common presenting features, and patients often are referred to …

Research on Alzheimer's disease (AD) has classically focused on alterations that occur in
the brain and their intra-and extracellular neuropathological hallmarks. However, the oxi …

Background Transthyretin amyloidosis, or ATTR, is a progressive and debilitating rare
proteopathy generally manifested as either transthyretin amyloid polyneuropathy (ATTR-PN) …

Segments of proteins with high β-strand propensity can self-associate to form amyloid fibrils
implicated in many diseases. We describe a general approach to bind such segments in β …

Apolipoprotein A-II (apoA-II) is the second most abundant apolipoprotein in high-density
lipoprotein (HDL) particles, playing an important role in lipid metabolism. Human and murine …

More than 35 amyloid precursor proteins have been identified and many have tropism for
the kidney. Renal amyloidosis is most commonly seen in AL and AA amyloidosis and the …

Renal amyloidosis is a rare condition caused by the progressive accumulation of misfolded
proteins within glomeruli, vessels, and interstitium, causing functional decline and requiring …