In this review article, we discuss the current state of computational modelling of the nuclear
factor-kappa B (NF-κ B) signalling pathway. NF-κ B is a transcription factor, which is …

Several transcription factors (TFs) oscillate, periodically relocating between the cytoplasm
and the nucleus. NF-κB, which plays key roles in inflammation and cancer, displays …

In this review, we aim at describing the results obtained in the past years on dynamics
features defining NF-κB regulatory functions, as we believe that these developments might …

Intracranial aneurysms are associated with disturbed velocity patterns, and chronic
inflammation, but the relevance for these findings are currently unknown. Here, we show that …

NF-κB is a transcription factor that upon activation undergoes cycles of cytoplasmic-to-
nuclear and nuclear-to-cytoplasmic transport, giving rise to so called “oscillations”. In turn …

Eukaryotic transcription factors in the NF-κB family are central components of an extensive
genetic network that activates cellular responses to inflammation and to a host of other …

Nuclear factor (NF)-κB controls the transcriptional response to inflammatory signals by
translocating into the nucleus, but we lack a single-cell characterization of the resulting …

Introduction: Drug-induced liver injury (DILI) is a significant threat to human health and a
major problem in drug development. It is hard to predict due to its idiosyncratic nature and …

Elevated temperature induces the heat shock (HS) response, which modulates cell
proliferation, apoptosis, the immune and inflammatory responses. However, specific …

An overwhelming majority of mathematical models of regulatory pathways, including the
intensively studied NF-κ B pathway, remains non-identifiable, meaning that their parameters …