[HTML][HTML] Liver ischaemia–reperfusion injury: a new understanding of the role of innate immunity

H Hirao, K Nakamura… - … reviews Gastroenterology & …, 2022 - nature.com
Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …

[HTML][HTML] Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

H Sies, DP Jones - Nature reviews Molecular cell biology, 2020 - nature.com
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

[HTML][HTML] The gut metabolite indole-3 propionate promotes nerve regeneration and repair

E Serger, L Luengo-Gutierrez, JS Chadwick, G Kong… - Nature, 2022 - nature.com
The regenerative potential of mammalian peripheral nervous system neurons after injury is
critically limited by their slow axonal regenerative rate. Regenerative ability is influenced by …

Reactive oxygen species (ROS)-based nanomedicine

B Yang, Y Chen, J Shi - Chemical reviews, 2019 - ACS Publications
Reactive oxygen species (ROS) play an essential role in regulating various physiological
functions of living organisms. The intrinsic biochemical properties of ROS, which underlie …

[HTML][HTML] Oxidative eustress: On constant alert for redox homeostasis

H Sies - Redox Biology, 2021 - Elsevier
In the open metabolic system, redox-related signaling requires continuous monitoring and
fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a …

[HTML][HTML] Functional nanomaterials in peripheral nerve regeneration: scaffold design, chemical principles and microenvironmental remodeling

Y Qian, H Lin, Z Yan, J Shi, C Fan - Materials Today, 2021 - Elsevier
Neuronal microenvironment imbalance is associated with successive and irreversible
pathophysiological changes and insufficient functional restoration after peripheral nerve …

Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases

Y Fan, Z Chen, M Zhang - Journal of Translational Medicine, 2022 - Springer
Central nervous system (CNS) diseases, such as multiple sclerosis, Alzheimer's disease
(AD), and Parkinson's disease (PD), affect millions of people around the world. Great efforts …

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

W Yang, Y Tao, Y Wu, X Zhao, W Ye, D Zhao… - Nature …, 2019 - nature.com
Phagocytes, including neutrophils and macrophages, have been suggested to function in a
cooperative way in the initial phase of inflammatory responses, but their interaction and …

Exosome biochemistry and advanced nanotechnology for next‐generation theranostic platforms

B Yang, Y Chen, J Shi - Advanced Materials, 2019 - Wiley Online Library
Recent marked technological advances in the field of exosome nanotechnology have
provided unprecedented opportunities to bloom the developments of exosome‐related …

The integration of inflammaging in age-related diseases

T Fulop, JM Witkowski, F Olivieri, A Larbi - Seminars in immunology, 2018 - Elsevier
Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …