Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many
critical cellular processes including proliferation, survival, and migration, as well as …

S1P is a small bioactive lipid which exerts its effects following binding to a family of five G
protein-coupled receptors, known as S1P 1–5. Following receptor activation, multiple …

Sphingosine 1-phosphate (S1P) is released at sites of tissue injury and effects cellular
responses through activation of G protein-coupled receptors. The role of S1P in regulating …

FTY720 is a novel immunomodulating drug that can be phosphorylated inside cells; its
phosphorylated form, FTY720-P, binds to a sphingosine 1-phosphate (S1P) receptor, S1P 1 …

The discovery of lysophospholipid (LP) 7‐transmembrane, G protein‐coupled receptors
(GPCRs) that began in the 1990s, together with research into the functional roles of the …

Alterations in sphingolipid metabolism have been shown to contribute to the development of
endocrine resistance and breast cancer tumor survival. Sphingosine kinase (SK), in …

USP14 is a deubiquitinating enzyme involved in protein degradation by interacting with the
proteasome and removal of poly-ubiquitin chains on target proteins. USP14 can influence …

The recent identification of a cellular balance between ceramide and sphingosine 1-
phosphate (S1P) as a critical regulator of cell growth and death has stimulated increasing …

Sphingosine-1-phosphate (S1P) is a pleiotropic sphingophospholipid generated from the
phosphorylation of sphingosine by sphingosine kinases (SPHKs). S1P has been …

Abstract Sphingosine-1-phosphate (S1P) can regulate several physiological and
pathological processes. S1P signaling via its cell surface receptor S1PR1 has been shown …