Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility

NJ Spencer, H Hu - Nature reviews Gastroenterology & hepatology, 2020 - nature.com
The gastrointestinal tract is the only internal organ to have evolved with its own independent
nervous system, known as the enteric nervous system (ENS). This Review provides an …

Gut feelings: mechanosensing in the gastrointestinal tract

A Mercado-Perez, A Beyder - Nature Reviews Gastroenterology & …, 2022 - nature.com
The primary function of the gut is to procure nutrients. Synchronized mechanical activities
underlie nearly all its endeavours. Coordination of mechanical activities depends on …

Gut microbiota-motility interregulation: insights from in vivo, ex vivo and in silico studies

B Waclawiková, A Codutti, K Alim, S El Aidy - Gut microbes, 2022 - Taylor & Francis
The human gastrointestinal tract is home to trillions of microbes. Gut microbial communities
have a significant regulatory role in the intestinal physiology, such as gut motility. Microbial …

Interstitial cells of Cajal and human colon motility in health and disease

JD Huizinga, A Hussain… - American Journal of …, 2021 - journals.physiology.org
Our understanding of human colonic motility, and autonomic reflexes that generate motor
patterns, has increased markedly through high-resolution manometry. Details of the motor …

[HTML][HTML] PIEZO2 in somatosensory neurons controls gastrointestinal transit

MR Servin-Vences, RM Lam, A Koolen, Y Wang… - Cell, 2023 - cell.com
The gastrointestinal tract is in a state of constant motion. These movements are tightly
regulated by the presence of food and help digestion by mechanically breaking down and …

Ca2+ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract

KM Sanders, BT Drumm, CA Cobine… - Physiological …, 2024 - journals.physiology.org
The gastrointestinal (GI) tract displays multiple motor patterns that move nutrients and
wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI …

Spontaneous electrical activity and rhythmicity in gastrointestinal smooth muscles

KM Sanders - Smooth muscle spontaneous activity: Physiological …, 2019 - Springer
The gastrointestinal (GI) tract has multifold tasks of ingesting, processing, and assimilating
nutrients and disposing of wastes at appropriate times. These tasks are facilitated by several …

Listen to your gut: key concepts for bioengineering advanced models of the intestine

O Cameron, JF Neves, E Gentleman - Advanced Science, 2024 - Wiley Online Library
The intestine performs functions central to human health by breaking down food and
absorbing nutrients while maintaining a selective barrier against the intestinal microbiome …

Functional intraregional and interregional heterogeneity between myenteric glial cells of the colon and duodenum in mice

L Seguella, JL McClain, G Esposito… - Journal of …, 2022 - Soc Neuroscience
Enteric glia are a unique population of peripheral neuroglia that regulate homeostasis in the
enteric nervous system (ENS) and intestinal functions. Despite existing in functionally …

Identification of a rhythmic firing pattern in the enteric nervous system that generates rhythmic electrical activity in smooth muscle

NJ Spencer, TJ Hibberd, L Travis… - Journal of …, 2018 - Soc Neuroscience
The enteric nervous system (ENS) contains millions of neurons essential for organization of
motor behavior of the intestine. It is well established that the large intestine requires ENS …