[HTML][HTML] Exosomes as powerful engines in cancer: isolation, characterization and detection techniques

MG Saad, H Beyenal, WJ Dong - Biosensors, 2021 - mdpi.com
Exosomes, powerful extracellular nanovesicles released from almost all types of living cells,
are considered the communication engines (messengers) that control and reprogram …

[HTML][HTML] Extracellular vesicle microRNA quantification from plasma using an integrated microfluidic device

Z Ramshani, C Zhang, K Richards, L Chen… - Communications …, 2019 - nature.com
Extracellular vesicles (EV) containing microRNAs (miRNAs) have tremendous potential as
biomarkers for the early detection of disease. Here, we present a simple and rapid PCR-free …

Liquid biopsy technologies based on membrane microfluidics: High‐yield purification and selective quantification of biomarkers in nanocarriers

C Wang, S Senapati, HC Chang - Electrophoresis, 2020 - Wiley Online Library
Liquid biopsy, screening cancer non‐invasively and frequently by detecting and quantifying
molecular markers in physiological fluids, would significantly improve cancer survival rate …

Ionic amplifying circuits inspired by electronics and biology

RA Lucas, CY Lin, LA Baker, ZS Siwy - Biophysical Journal, 2020 - cell.com
Biological ion channels are a fundamental component of all cells and enable an immense
amount of processes which are essential for life. Some of these channels possess inherently …

Human heart anoxia and reperfusion tissue (HEART) model for the rapid study of exosome bound miRNA expression as biomarkers for myocardial infarction

BW Ellis, G Ronan, X Ren, G Bahcecioglu, S Senapati… - Small, 2022 - Wiley Online Library
Current biomarkers for myocardial infarction (MI) diagnosis are typically late markers
released upon cell death, incapable of distinguishing between ischemic and reperfusion …

Microvalve-Based tunability of electrically driven Ion transport through a microfluidic system with an ion-exchange membrane

B Sabbagh, S Park, G Yossifon - Analytical Chemistry, 2023 - ACS Publications
Microfluidic channels with an embedded ion permselective medium under the application of
electric current are commonly used for electrokinetic processes as on-chip ion concentration …

A multiplexed ion-exchange membrane-based miRNA (MIX· miR) detection platform for rapid diagnosis of myocardial infarction

X Ren, BW Ellis, G Ronan, SR Blood, C DeShetler… - Lab on a Chip, 2021 - pubs.rsc.org
Micro RNAs (miRNAs) have shown great potential as rapid and discriminating biomarkers
for acute myocardial infarction (AMI) diagnosis. We have developed a multiplexed ion …

A multiplexed immuno-sensor for on-line and automated monitoring of tissue culture protein biomarkers

Z Ramshani, F Fan, A Wei… - Talanta, 2021 - Elsevier
Frequent on-line and automated monitoring of multiple protein biomarkers level secreted in
the culture media during tissue growth is essential for the successful development of Tissue …

A bifurcated continuous field-flow fractionation (BCFFF) chip for high-yield and high-throughput nucleic acid extraction and purification

C Zhang, G Sun, S Senapati, HC Chang - Lab on a Chip, 2019 - pubs.rsc.org
We report a bifurcated continuous field-flow fractionation (BCFFF) chip for high-yield and
high-throughput (20 min) extraction of nucleic acids from physiological samples. The design …

Surface enhanced Raman scattering (SERS) based biomicrofluidics systems for trace protein analysis

CW Lee, FG Tseng - Biomicrofluidics, 2018 - pubs.aip.org
In recent years, Surface Enhanced Raman Scattering (SERS) has been widely applied to
many different areas, including chemical analysis, biomolecule detection, bioagent …