Arsenic and human health effects: A review

KSM Abdul, SS Jayasinghe, EPS Chandana… - Environmental …, 2015 - Elsevier
Arsenic (As) is ubiquitous in nature and humans being exposed to arsenic via atmospheric
air, ground water and food sources are certain. Major sources of arsenic contamination …

[HTML][HTML] Metabolism, toxicity and anticancer activities of arsenic compounds

I Khairul, QQ Wang, YH Jiang, C Wang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
A variety of studies indicated that inorganic arsenic and its methylated metabolites have
paradoxical effects, namely, carcinogenic and anticancer effects. Epidemiological studies …

Mechanistic understanding of the toxic effects of arsenic and warfare arsenicals on human health and environment

S Muzaffar, J Khan, R Srivastava, MS Gorbatyuk… - Cell Biology and …, 2023 - Springer
Worldwide, more than 200 million people are estimated to be exposed to unsafe levels of
arsenic. Chronic exposure to unsafe levels of groundwater arsenic is responsible for …

Arsenic and human health: genotoxicity, epigenomic effects, and cancer signaling

M Ozturk, M Metin, V Altay, RA Bhat, M Ejaz… - … Trace Element Research, 2022 - Springer
Arsenic is a well-known element because of its toxicity. Humans as well as plants and
animals are negatively affected by its exposure. Some countries suffer from high levels of …

A review on arsenic carcinogenesis: epidemiology, metabolism, genotoxicity and epigenetic changes

Q Zhou, S Xi - Regulatory Toxicology and Pharmacology, 2018 - Elsevier
Long-term exposure to arsenic (inorganic arsenic) is a world-wide environmental health
concern. Arsenic is classified as the Group 1 human carcinogen by the International Agency …

[HTML][HTML] Connections between endoplasmic reticulum stress-associated unfolded protein response, mitochondria, and autophagy in arsenic-induced carcinogenesis

P Wadgaonkar, F Chen - Seminars in cancer biology, 2021 - Elsevier
Arsenic exposure in contaminated drinking water is a global health issue, as more than 200
million people are affected globally. Arsenic has been known to cause skin, liver, lung …

Role of endoplasmic reticulum stress in drug‐induced toxicity

F Foufelle, B Fromenty - Pharmacology research & …, 2016 - Wiley Online Library
Drug‐induced toxicity is a key issue for public health because some side effects can be
severe and life‐threatening. These adverse effects can also be a major concern for the …

Arsenic-induced lung inflammation and fibrosis in a rat model: Contribution of the HMGB1/RAGE, PI3K/AKT, and TGF-β1/SMAD pathways

W Wang, F Zheng, A Zhang - Toxicology and Applied Pharmacology, 2021 - Elsevier
An increasing number of studies have shown that arsenic exposure increases the risk of
lung cancer as well as a variety of non-malignant respiratory diseases, including bronchitis …

Arsenic speciation, mechanisms, and factors affecting rice uptake and potential human health risk: A systematic review

T Sarwar, S Khan, S Muhammad, S Amin - Environmental Technology & …, 2021 - Elsevier
Arsenic (As), being the first class of carcinogen, reflects disastrous threats to living beings
owing to its high persistence, toxicity, bioaccumulation, and bioavailability in the …

The mechanistic basis of arsenicosis: pathogenesis of skin cancer

KM Hunt, RK Srivastava, CA Elmets, M Athar - Cancer letters, 2014 - Elsevier
Significant amounts of arsenic have been found in the groundwater of many countries
including Argentina, Bangladesh, Chile, China, India, Mexico, and the United States with an …