Membrane lipid homeostasis is a vital facet of bacterial cell physiology. For decades,
research in bacterial lipid synthesis was largely confined to the Escherichia coli model …

This review presents the most thoroughly studied bacterial fatty acid synthetic pathway, that
of Escherichia coli and then discusses the exceptions to the E. coli pathway present in other …

Tuberculosis (TB) is a global public health emergency. Increasingly drug resistant strains of
Mycobacterium tuberculosis (M. tb) continue to emerge and spread, highlighting adaptability …

The mycobacterial cell wall is essential for Mycobacterium tuberculosis growth and survival.
It is lipid‐rich and highly impermeable and thereby provides protection from many …

The enzyme β-Ketoacyl ACP synthase I (KasA) is a potent drug target in mycolic acid
pathway of Mycobacterium tuberculosis (Mtb). In the present study, we investigated the …

Upon infection, Mycobacterium leprae, an obligate intracellular bacillus, induces
accumulation of cholesterol-enriched lipid droplets (LDs) in Schwann cells (SCs). LDs are …

Mycolic acids are hallmark features of the Mycobacterium tuberculosis cell wall. They are
synthesized by the condensation of two fatty acids, a C 56-64-meromycolyl chain and a C 24 …

Abundant mycolic acids are the hallmark of the mycobacterial cell wall. The biosynthesis of
mycolic acids fulfilled by type I (Fas-I) and type II (Fas-II) synthase systems necessitates long …

Objectives Enoyl acyl-carrier-protein reductase (InhA), the primary endogenous target for
isoniazid and ethionamide, is crucial to type-II fatty acid biosynthesis (FAS-II). The objectives …

The use of chemical techniques to study biological systems (often referred to currently as
chemical biology) has become a powerful tool for both drug discovery and the development …