ADAMTS proteins are a superfamily of 26 secreted molecules comprising two related, but
distinct families. ADAMTS proteases are zinc metalloendopeptidases, most of whose …

A disintegrin and metalloprotease with thrombospondin type I motifs (ADAMTS) proteases
are secreted metalloproteinases that play key roles in the formation, homeostasis and …

Remodelling of the extracellular matrix (ECM) by ECM metalloproteinases is increasingly
being associated with regulation of immune cell function. ECM metalloproteinases, including …

Proteoglycans are composite molecules comprising a protein backbone, ie, the core protein,
with covalently attached glycosaminoglycan chains of distinct chemical types. Most …

Extracellular matrix (ECM) determines the physiological function of all tissues, including
musculoskeletal tissues. In tendon, ECM provides overall tissue architecture, which is …

The physiology of connective tissues like tendons and ligaments is highly dependent upon
the collagens and other such extracellular matrix molecules hierarchically organized within …

Tendons and ligaments are fibrous connective tissues vital to the transmission of force and
stabilization of the musculoskeletal system. Arising in precise regions of the embryo …

Hedgehog (Hh) signaling has been widely acknowledged to play essential roles in many
developmental processes, including endochondral ossification and growth plate …

Chondroitin sulfate (CS) is an important extracellular matrix component of mineralized
tissues. It participates in biomineralization, osteoblast differentiation and promotes bone …

Rationale: Despite contemporary therapy, coronary artery disease (CAD) remains a leading
cause of mortality. Genetic variants at ADAMTS7 have been associated with CAD and the …