The heterogeneity of late-life depression and its pathobiology: a brain network dysfunction disorder

KA Jellinger - Journal of Neural Transmission, 2023 - Springer
Depression is frequent in older individuals and is often associated with cognitive impairment
and increasing risk of subsequent dementia. Late-life depression (LLD) has a negative …

Neural substrates for late-life depression: a selective review of structural neuroimaging studies

YK Kim, KM Han - Progress in Neuro-Psychopharmacology and …, 2021 - Elsevier
Recent neuroimaging studies have characterized the pathophysiology of late-life depression
(LLD) as a dysfunction of the brain networks involved in the regulation of emotion …

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

X Shen, DM Howard, MJ Adams, WD Hill… - Nature …, 2020 - nature.com
Depression is a leading cause of worldwide disability but there remains considerable
uncertainty regarding its neural and behavioural associations. Here, using non-overlapping …

[HTML][HTML] The role of brain structure in the association between pubertal timing and depression risk in an early adolescent sample (the ABCD Study®): A registered …

N MacSweeney, J Allardyce, A Edmondson-Stait… - Developmental …, 2023 - Elsevier
Background Earlier pubertal timing is associated with higher rates of depressive disorders in
adolescence. Neuroimaging studies report brain structural associations with both pubertal …

3D sprayed polyurethane functionalized graphene/carbon nanotubes hybrid architectures to enhance the piezo-resistive response of quantum resistive pressure …

MT Tran, TT Tung, A Sachan, D Losic, M Castro… - Carbon, 2020 - Elsevier
Abstract Quantum Resistive pressure Sensors (pQRS) can be integrated into flexible
electronics, smart textiles, robotics etc. Our last research on hybrid nanocomposites by 3D …

Brain structural associations with depression in a large early adolescent sample (the ABCD study®)

X Shen, N MacSweeney, SWY Chan, MC Barbu… - …, 2021 - thelancet.com
Background Depression is the leading cause of disability worldwide with> 50% of cases
emerging before the age of 25 years. Large-scale neuroimaging studies in depression …

Brain-based mechanisms of late-life depression: implications for novel interventions

FM Gunning, LE Oberlin, M Schier… - Seminars in cell & …, 2021 - Elsevier
Late-life depression (LLD) is a particularly debilitating illness. Older adults suffering from
depression commonly experience poor outcomes in response to antidepressant treatments …

Age-related changes of peak width skeletonized mean diffusivity (PSMD) across the adult lifespan: a multi-cohort study

G Beaudet, A Tsuchida, L Petit, C Tzourio… - Frontiers in …, 2020 - frontiersin.org
Parameters of water diffusion in white matter derived from diffusion-weighted imaging (DWI),
such as fractional anisotropy (FA), mean, axial, and radial diffusivity (MD, AD, and RD), and …

Automated classification of depression from structural brain measures across two independent community‐based cohorts

A Stolicyn, MA Harris, X Shen, MC Barbu… - Human brain …, 2020 - Wiley Online Library
Major depressive disorder (MDD) has been the subject of many neuroimaging case–control
classification studies. Although some studies report accuracies≥ 80%, most have …

Elevated homocysteine levels, white matter abnormalities and cognitive impairment in patients with late-life depression

H Zhou, X Zhong, B Chen, Q Wang, M Zhang… - Frontiers in aging …, 2022 - frontiersin.org
Background Cognitive impairment in late− life depression (LLD) is considered to be caused
by neurodegenerative changes. Elevated homocysteine (Hcy) levels may be linked to …