How DNA is organized in three dimensions inside the cell nucleus and how this affects the
ways in which cells access, read and interpret genetic information are among the longest …

Diabetic nephropathy (DN), a severe microvascular complication frequently associated with
both type 1 and type 2 diabetes mellitus, is a leading cause of renal failure. The condition …

Motivation Deciphering the language of non-coding DNA is one of the fundamental
problems in genome research. Gene regulatory code is highly complex due to the existence …

The Enc yclopedia of D NA E lements (ENCODE) Data Coordinating Center has developed
the ENCODE Portal database and website as the source for the data and metadata …

While genome assembly projects have been successful in many haploid and inbred
species, the assembly of noninbred or rearranged heterozygous genomes remains a major …

Abstract The Encyclopedia of DNA Elements (ENCODE), http://encodeproject. org, has
completed its fifth year of scientific collaboration to create a comprehensive catalog of …

DNase I hypersensitive sites (DHSs) provide important information on the presence of
transcriptional regulatory elements and the state of chromatin in mammalian cells …

The CRISPR-Cas9 system has recently emerged as a versatile tool for biological and
medical research. In this system, a single guide RNA (sgRNA) directs the endonuclease …

Primate genomics holds the key to understanding fundamental aspects of human evolution
and disease. However, genetic diversity and functional genomics data sets are currently …

Experience-dependent gene transcription is required for nervous system development and
function. However, the DNA regulatory elements that control this program of gene …