As population genomic datasets grow in size, researchers are faced with the daunting task
of making sense of a flood of information. To keep pace with this explosion of data …

Ecological systems can often be characterised by changes among a finite set of underlying
states pertaining to individuals, populations, communities or entire ecosystems through time …

Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

Stochastic simulation is a key tool in population genetics, since the models involved are
often analytically intractable and simulation is usually the only way of obtaining ground-truth …

Virus host shifts are generally associated with novel adaptations to exploit the cells of the
new host species optimally. Surprisingly, Severe Acute Respiratory Syndrome Coronavirus …

Abstract HYpothesis testing using PHYlogenies (HyPhy) is a scriptable, open-source
package for fitting a broad range of evolutionary models to multiple sequence alignments …

Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …

Mammalian genomes contain thousands of loci that transcribe long noncoding RNAs
(lncRNAs),, some of which are known to carry out critical roles in diverse cellular processes …

INTRODUCTION Coral reefs worldwide are suffering losses at an alarming rate as a result of
anthropogenic climate change. Increased seawater temperatures, even only slightly above …

Mutations create variation in the population, fuel evolution and cause genetic diseases.
Current knowledge about de novo mutations is incomplete and mostly indirect,,,,,,,,,. Here we …