Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)

ZA Sherif, CR Gomez, TJ Connors, TJ Henrich… - Elife, 2023 - elifesciences.org
COVID-19, with persistent and new onset of symptoms such as fatigue, post-exertional
malaise, and cognitive dysfunction that last for months and impact everyday functioning, is …

A review of cytokine-based pathophysiology of Long COVID symptoms

RN Low, RJ Low, A Akrami - Frontiers in Medicine, 2023 - frontiersin.org
The Long COVID/Post Acute Sequelae of COVID-19 (PASC) group includes patients with
initial mild-to-moderate symptoms during the acute phase of the illness, in whom recovery is …

Understanding long COVID; mitochondrial health and adaptation—old pathways, new problems

AVW Nunn, GW Guy, W Brysch, JD Bell - Biomedicines, 2022 - mdpi.com
Many people infected with the SARS-CoV-2 suffer long-term symptoms, such as “brain fog”,
fatigue and clotting problems. Explanations for “long COVID” include immune imbalance …

COVID-19 and long COVID: Disruption of the neurovascular unit, blood-brain barrier, and tight junctions

D Kempuraj, KK Aenlle, J Cohen… - The …, 2024 - journals.sagepub.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), could affect brain structure and function. SARS-CoV …

A pilot study on the immune cell proteome of long COVID patients shows changes to physiological pathways similar to those in myalgic encephalomyelitis/chronic …

K Peppercorn, CD Edgar, T Kleffmann, WP Tate - Scientific Reports, 2023 - nature.com
Of those infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),~
10% develop the chronic post-viral debilitating condition, long COVID (LC). Although LC is a …

Neurological post‐acute sequelae of SARS‐CoV‐2 infection

M Takao, M Ohira - Psychiatry and Clinical Neurosciences, 2023 - Wiley Online Library
The novel coronavirus disease 19 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), can have two phases: acute (generally 4 weeks …

[HTML][HTML] Brain-regional characteristics and neuroinflammation in ME/CFS patients from neuroimaging: A systematic review and meta-analysis

JS Lee, W Sato, CG Son - Autoimmunity Reviews, 2023 - Elsevier
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition
characterized by an elusive etiology and pathophysiology. This study aims to evaluate the …

Towards a better understanding of the complexities of myalgic encephalomyelitis/chronic fatigue syndrome and long COVID

WP Tate, MOM Walker, K Peppercorn… - International Journal of …, 2023 - mdpi.com
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex condition
arising in susceptible people, predominantly following viral infection, but also other stressful …

Long COVID (PASC) is maintained by a self-sustaining pro-inflammatory TLR4/RAGE-loop of S100A8/A9> TLR4/RAGE signalling, inducing chronic expression of IL …

RD Holms - Immuno, 2022 - mdpi.com
Long COVID, also referred to as Post-Acute Sequelae of COVID (PASC), is probably
triggered during SARS-CoV-2 infection and acute COVID-19 by SARS-CoV-2 Spike-protein …

[HTML][HTML] Chronic inflammation, neuroglial dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID …

AM Chaves-Filho, O Braniff, A Angelova, Y Deng… - Brain Research …, 2023 - Elsevier
After five waves of coronavirus disease 2019 (COVID-19) outbreaks, it has been recognized
that a significant portion of the affected individuals developed long-term debilitating …