Degenerative, calcific valvular aortic stenosis (AS), caused by an active process of
atherosclerosis, calcification and ossification, is the most common cause of AS in …

Untreated, severe, symptomatic aortic stenosis is associated with a dismal prognosis. The
only treatment shown to improve survival is aortic valve replacement; however, before …

Objectives: The goal of this study was to assess the prognostic significance of midwall and
infarct patterns of late gadolinium enhancement (LGE) in aortic stenosis. Background …

Some 12 years ago, a polymorphism of the angiotensin I-converting enzyme (ACE) gene
became the first genetic element shown to impact substantially on human physical …

Background Cardiovascular magnetic resonance (CMR) is the gold standard non-invasive
method for determining left ventricular (LV) mass and volume but has not been used …

Aims In aortic stenosis (AS), left ventricular (LV) hypertrophy is considered a compensatory
response helping maintain systolic function. Recent research in experimental AS suggests …

BACKGROUND: Valve prosthesis-patient mismatch is a frequent problem in patients
undergoing aortic valve replacement and its main hemodynamic consequence is to …

Pressure and volume overload results in concentric and eccentric hypertrophy of cardiac
ventricular chambers with, respectively, parallel and series replication of sarcomeres. These …

Objectives: The aim of this study was to investigate the long-term clinical and hemodynamic
outcomes after aortic valve replacement with the Carpentier-Edwards Perimount …

Background: Hypertrophic cardiomyopathy (HCM) is an inherited disease of the sarcomere
characterised clinically by myocardial hypertrophy and its consequences. Phenotypic …